(R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-1-N-Boc-2-methylpiperazine
CAS: 169447-70-5
Molecular Formula: C10H20N2O2
(R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER - Names and Identifiers
(R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER - Physico-chemical Properties
| Molecular Formula | C10H20N2O2 |
| Molar Mass | 200.28 |
| Density | 0.997±0.06 g/cm3(Predicted) |
| Melting Point | 43.0 to 47.0 °C |
| Boling Point | 268.7±15.0 °C(Predicted) |
| Flash Point | 116.33°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.008mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 8.49±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.459 |
| MDL | MFCD01862121 |
(R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER - Risk and Safety
| UN IDs | UN3077 |
(R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER - Reference Information
| application | (S)-1-N-Boc-2-methylpiperazine has a wide range of applications in the fields of medicinal chemistry, organic chemistry, materials, etc., and is also a key drug intermediate in the process research of antipsychotic drugs. |
| synthesis method | 1, 1-dimethylethyl (2S)-2-methyl-1-piperazine carboxylate (step a) solution and n-BuLi(25 mL) stored in THF(200 mL) at room temperature, 1.6 M stored in hexane, 40 mmol) mixed. Stir the solution for 30 min, then add TBDMSCl(3.04 g,20mm ol). Stir the mixture for an extra hour and add (Boc)2O(5.2g,24 mmol) to the solution. The resulting mixture was stirred for one hour and diluted with H2O(50 mL). The organic layer was separated, washed with salt water (50 mL), dried on Na2SO4 and concentrated under vacuum. Rapid chromatography on silica gel (5% MeOH/2% NH4OH/93% CH2Cl2) provided yellow oily title compounds (3.7 g,93%). (S)-1-N-Boc-2-methylpiperazine, yield (3.7g,93%). Fig. (S)-synthesis route of 1-N-Boc-2-methylpiperazine |
Last Update：2024-04-09 21:21:28
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